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Abstract

Microfluidic system has been a powerful platform for cellular studies such as cell manipulation, cell sensing and cell engineering due to its advantages in precise control, small sample volume requirement, high throughput, low cost and high compatibility. Acoustic microfluidics has emerged as a powerful and novel platform for micro/nano manipulation in many applications recently due to its advantages in versatility, low cost, easy to integrate and manufacture, miniaturization, energy efficiency, etc. Here, I will first introduce our most recent breakthroughs on acoustic manipulation, including (1) internal structure manipulation of colloids using acoustic waves, (2) acoustic Gym for animal neurodegenerative studies, and (3) reconfigurable acoustic tweezers that can in-situ switch manipulating physics mechanisms on demand. Secondly, I will present our recent progress on cell membrane mechanical disruption and recovery dynamics studies enabled by microfluidics. Such membrane disruption-based method shows great potential for precise intracellular and nuclear delivery that would benefit a broad biomedical field including gene editing, immunotherapy, and other cell engineering.

About the Speaker

Dr. Xiaoyun Ding is currently a Harrington faculty fellow at University of Texas at Austin, and Bruce S. Anderson Associate Professor of Mechanical Engineering, Biomedical Engineering, Materials Science and Engineering, and BioFrontiers Institute at University of Colorado Boulder. Before joining CU Boulder in 2017, he received his B.S. degree in MSE from Fudan University (2006), MS degree in Microelectronics from Shanghai Institute of Microsystem and Information Technology (2009), Ph.D. from The Pennsylvania State University (2013) and postdoctoral training from MIT. His current research interests are focused on Microfluidics and Biomedical devices. His work has led to leading journal publications (including Nature Biomedical Engineering, Nature, Nature Comms, Sci Adv, PNAS, PRL, etc.), 10 US patents (6 issued), and a number of prestigious awards such as Harrington Faculty Fellowship 2024, RIO faculty fellow 2023, NIH MIRA Award 2021, W.M. Keck Foundation medical research Award 2019, Chancellor’s Research Innovation Award 2021, Colorado Lab Venture Challenge Award 2021&2023, Biomaterials Science emerging investigators Award 2021, Penn State Graduate School Alumni Society Early Career Award 2022, Baxter Young Investigator Award, Rustum & Della Roy Innovation in Materials Research Award, etc.